| 09/12/05 | at | Atlanta | 10-14 |
| 09/18/05 | hosting | San Francisco | 42-3 |
| 09/25/05 | hosting | Oakland | 23-20 |
| 10/02/05 | at | Kansas City | 31-37 |
| 10/09/05 | at | Dallas | 10-33 |
| 10/23/05 | hosting | San Diego | 20-17 |
| 10/30/05 | at | Denver | 21-49 |
| 11/06/05 | at | Washington | 10-17 |
| 11/14/05 | hosting | Dallas | 20-21 |
| 11/20/05 | at | N.Y. Giants | 17-27 |
| 11/27/05 | hosting | Green Bay | 19-14 |
| 12/05/05 | hosting | Seattle | 0-42 |
| 12/11/05 | hosting | N.Y. Giants | 23-26 OT |
| 12/18/05 | at | St. Louis | 17-16 |
| 12/24/05 | at | Arizona | 21-27 |
| 01/01/06 | hosting | Washington | 20-31 |