| 09/11/05 | hosting | Arizona | 42-19 |
| 09/19/05 | hosting | New Orleans | 27-10 |
| 09/25/05 | at | San Diego | 23-45 |
| 10/02/05 | hosting | St. Louis | 44-24 |
| 10/16/05 | at | Dallas | 13-16 OT |
| 10/23/05 | hosting | Denver | 24-23 |
| 10/30/05 | hosting | Washington | 36-0 |
| 11/06/05 | at | San Francisco | 24-6 |
| 11/13/05 | hosting | Minnesota | 21-24 |
| 11/20/05 | hosting | Philadelphia | 27-17 |
| 11/27/05 | at | Seattle | 21-24 OT |
| 12/04/05 | hosting | Dallas | 17-10 |
| 12/11/05 | at | Philadelphia | 26-23 OT |
| 12/17/05 | hosting | Kansas City | 27-17 |
| 12/24/05 | at | Washington | 20-35 |
| 12/31/05 | at | Oakland | 30-21 |
| 01/08/06 | hosting | Carolina | 0-23 |