| 09/11/05 | hosting | N.Y. Jets | 27-7 |
| 09/18/05 | at | Oakland | 23-17 |
| 09/26/05 | at | Denver | 10-30 |
| 10/02/05 | hosting | Philadelphia | 37-31 |
| 10/16/05 | hosting | Washington | 28-21 |
| 10/21/05 | at | Miami | 30-20 |
| 10/30/05 | at | San Diego | 20-28 |
| 11/06/05 | hosting | Oakland | 27-23 |
| 11/13/05 | at | Buffalo | 3-14 |
| 11/20/05 | at | Houston | 45-17 |
| 11/27/05 | hosting | New England | 26-16 |
| 12/04/05 | hosting | Denver | 31-27 |
| 12/11/05 | at | Dallas | 28-31 |
| 12/17/05 | at | N.Y. Giants | 17-27 |
| 12/24/05 | hosting | San Diego | 20-7 |
| 01/01/06 | hosting | Cincinnati | 37-3 |