| 09/11/05 | at | Kansas City | 7-27 |
| 09/18/05 | hosting | Miami | 17-7 |
| 09/25/05 | hosting | Jacksonville | 20-26 OT |
| 10/02/05 | at | Baltimore | 3-13 |
| 10/09/05 | hosting | Tampa Bay | 14-12 |
| 10/16/05 | at | Buffalo | 17-27 |
| 10/24/05 | at | Atlanta | 14-27 |
| 11/06/05 | hosting | San Diego | 26-31 |
| 11/13/05 | at | Carolina | 3-30 |
| 11/20/05 | at | Denver | 0-27 |
| 11/27/05 | hosting | New Orleans | 19-21 |
| 12/04/05 | at | New England | 3-16 |
| 12/11/05 | hosting | Oakland | 26-10 |
| 12/18/05 | at | Miami | 20-24 |
| 12/26/05 | hosting | New England | 21-31 |
| 01/01/06 | hosting | Buffalo | 30-26 |