| 09/11/05 | hosting | Dallas | 24-28 |
| 09/18/05 | at | Denver | 17-20 |
| 09/25/05 | hosting | N.Y. Giants | 45-23 |
| 10/02/05 | at | New England | 41-17 |
| 10/10/05 | hosting | Pittsburgh | 22-24 |
| 10/16/05 | at | Oakland | 27-14 |
| 10/23/05 | at | Philadelphia | 17-20 |
| 10/30/05 | hosting | Kansas City | 28-20 |
| 11/06/05 | at | N.Y. Jets | 31-26 |
| 11/20/05 | hosting | Buffalo | 48-10 |
| 11/27/05 | at | Washington | 23-17 OT |
| 12/04/05 | hosting | Oakland | 34-10 |
| 12/11/05 | hosting | Miami | 21-23 |
| 12/18/05 | at | Indianapolis | 26-17 |
| 12/24/05 | at | Kansas City | 7-20 |
| 12/31/05 | hosting | Denver | 7-23 |