| 09/11/05 | at | San Diego | 28-24 |
| 09/19/05 | hosting | Washington | 13-14 |
| 09/25/05 | at | San Francisco | 34-31 |
| 10/02/05 | at | Oakland | 13-19 |
| 10/09/05 | hosting | Philadelphia | 33-10 |
| 10/16/05 | hosting | N.Y. Giants | 16-13 OT |
| 10/23/05 | at | Seattle | 10-13 |
| 10/30/05 | hosting | Arizona | 34-13 |
| 11/14/05 | at | Philadelphia | 21-20 |
| 11/20/05 | hosting | Detroit | 20-7 |
| 11/24/05 | hosting | Denver | 21-24 OT |
| 12/04/05 | at | N.Y. Giants | 10-17 |
| 12/11/05 | hosting | Kansas City | 31-28 |
| 12/18/05 | at | Washington | 7-35 |
| 12/24/05 | at | Carolina | 24-20 |
| 01/01/06 | hosting | St. Louis | 10-20 |