| 09/11/05 | hosting | New Orleans | 20-23 |
| 09/18/05 | hosting | New England | 27-17 |
| 09/25/05 | at | Miami | 24-27 |
| 10/03/05 | hosting | Green Bay | 32-29 |
| 10/09/05 | at | Arizona | 24-20 |
| 10/16/05 | at | Detroit | 21-20 |
| 10/30/05 | hosting | Minnesota | 38-13 |
| 11/06/05 | at | Tampa Bay | 34-14 |
| 11/13/05 | hosting | N.Y. Jets | 30-3 |
| 11/20/05 | at | Chicago | 3-13 |
| 11/27/05 | at | Buffalo | 13-9 |
| 12/04/05 | hosting | Atlanta | 24-6 |
| 12/11/05 | hosting | Tampa Bay | 10-20 |
| 12/18/05 | at | New Orleans | 27-10 |
| 12/24/05 | hosting | Dallas | 20-24 |
| 01/01/06 | at | Atlanta | 44-11 |
| 01/08/06 | at | N.Y. Giants | 23-0 |
| 01/15/06 | at | Chicago | 29-21 |
| 01/22/06 | at | Seattle | 14-34 |