| 09/11/05 | at | Minnesota | 24-13 |
| 09/18/05 | hosting | Buffalo | 19-3 |
| 09/25/05 | at | Green Bay | 17-16 |
| 10/02/05 | hosting | Detroit | 17-13 |
| 10/09/05 | at | N.Y. Jets | 12-14 |
| 10/16/05 | hosting | Miami | 27-13 |
| 10/30/05 | at | San Francisco | 10-15 |
| 11/06/05 | hosting | Carolina | 14-34 |
| 11/13/05 | hosting | Washington | 36-35 |
| 11/20/05 | at | Atlanta | 30-27 |
| 11/27/05 | hosting | Chicago | 10-13 |
| 12/04/05 | at | New Orleans | 10-3 |
| 12/11/05 | at | Carolina | 20-10 |
| 12/17/05 | at | New England | 0-28 |
| 12/24/05 | hosting | Atlanta | 27-24 OT |
| 01/01/06 | hosting | New Orleans | 27-13 |
| 01/07/06 | hosting | Washington | 10-17 |