| 09/11/05 | hosting | Tampa Bay | 13-24 |
| 09/18/05 | at | Cincinnati | 8-37 |
| 09/25/05 | hosting | New Orleans | 33-16 |
| 10/02/05 | at | Atlanta | 10-30 |
| 10/16/05 | at | Chicago | 3-28 |
| 10/23/05 | hosting | Green Bay | 23-20 |
| 10/30/05 | at | Carolina | 13-38 |
| 11/06/05 | hosting | Detroit | 27-14 |
| 11/13/05 | at | N.Y. Giants | 24-21 |
| 11/21/05 | at | Green Bay | 20-17 |
| 11/27/05 | hosting | Cleveland | 24-12 |
| 12/04/05 | at | Detroit | 21-16 |
| 12/11/05 | hosting | St. Louis | 27-13 |
| 12/18/05 | hosting | Pittsburgh | 3-18 |
| 12/25/05 | at | Baltimore | 23-30 |
| 01/01/06 | hosting | Chicago | 34-10 |